Polymer (PCL) fibers with Zn‐doped mesoporous bioactive glass nanoparticles for tissue regeneration

Composite fibrous membranes based on poly(ɛ-caprolactone) (PCL) and mesoporous bioactive glass nanoparticles (MBGNs) were fabricated by electrospinning. MBGNs Zn-doped prepared microemulsion sol–gel method successfully incorporated inside the polymeric fibers of 240 385 nm in diameter for undoped PCL_MBGNs fibers, respectively. Thermal analysis showed that concentration reached a maximum around 21 wt% MBGNs. Both PCL_MBGNs_Zn composite membrane exhibited bioactivity after immersion simulated body fluid (SBF). X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FTIR) evolution membranes, confirming formation hydroxyapatite (HAp). However, degradation products did not affect viability proliferation murine stromal cells (ST-2) thus new fiber structures represent suitable environment cell adhesion. Therefore, incorporation doped with therapeutically active Zn2+ ions PCL offers possibility to create multifunctional biomaterial drug delivery tissue engineering.